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Ideal for those who dont want to wait on monthly delivery

The use of humanized mice was required, as it is well-established that human albumin binds poorly to mouse FcRn 13,70,71,72,73

Cons: Saxenda must be injected daily, which can be inconvenient

Cobalamins circulate bound to serum proteins called transcobalamins (TC) and haptocorrins

The Lau monotherapy data cuts through that by showing the amylin analog producing double-digit weight loss entirely on its own, which is the cleanest argument that adding it to a triple agonist brings genuinely additive firepower rather than redundant signalling

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